Design, analysis and presentation of factorial randomised controlled trials

Design , analysis and presentation of factorial randomised controlled trials ( 1 )

Design, analysis and presentation of factorial randomised controlled trials

BACKGROUND The evaluation of more than one intervention in the same randomised controlled trial can be achieved using a parallel group design. However this requires increased sample size and can be inefficient, especially if there is also interest in considering combinations of the interventions. An alternative may be a factorial trial, where for two interventions participants are allocated to ...

Bias in randomised factorial trials.

Factorial trials are an efficient method of assessing multiple treatments in a single trial, saving both time and resources. However, they rely on the assumption of no interaction between treatment arms. Ignoring the possibility of an interaction in the analysis can lead to bias and potentially misleading conclusions. Therefore, it is often recommended that the size of the interaction be assess...

Design, analysis, and presentation of crossover trials

OBJECTIVE Although crossover trials enjoy wide use, standards for analysis and reporting have not been established. We reviewed methodological aspects and quality of reporting in a representative sample of published crossover trials. METHODS We searched MEDLINE for December 2000 and identified all randomized crossover trials. We abstracted data independently, in duplicate, on 14 design criter...

Economic evaluation of factorial randomised controlled trials: challenges, methods and recommendations

Increasing numbers of economic evaluations are conducted alongside randomised controlled trials. Such studies include factorial trials, which randomise patients to different levels of two or more factors and can therefore evaluate the effect of multiple treatments alone and in combination. Factorial trials can provide increased statistical power or assess interactions between treatments, but ra...